Protein Details: Neuronal acetylcholine receptor subunit beta-2

Protein ID

ICDB_Pro_0320

Protein Name

Neuronal acetylcholine receptor subunit beta-2

Gene Name

CHRNB2

Organism

Gallus gallus (Chicken)

Length

491 amino acids

AlphaFoldDB

AF-P09484-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MALLRVLCLLAALRRSLCTDTEERLVEYLLDPTRYNKLIRPATNGSQLVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVISYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPPWVRTLFLRKLPALLFMKQPQQNCARQRLRQRRQTQERAAAATLFLRAGARACACYANPGAAKAEGLNGYRERQGQGPDPPAPCGCGLEEAVEGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPLFQNYATNSLLQLGQGTPTSK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 77: "Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site"; SITE 129: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"; SITE 137: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

DOI ID

10.1002/j.1460-2075.1988.tb02852.x; 10.1016/0896-6273(88)90145-6; 10.1038/350235a0

RefSeq

NP_990144.1